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Adjuvant therapy in septic neonates with immunoglobulin preparations containing Ig isotypes in addition to IgG: A critical review of current literature.

Letizia Capasso, Angela Carla Borrelli,Teresa Ferrara, Roberta Albachiara, Clara Coppola, Francesco Raimondi

Preterm VLBW neonates are extremely susceptible to sepsis and its consequences in terms of morbidity and mortality. This susceptibility to sepsis is related either to the immaturity of their immune system either to the exposure to invasive NICU maneuvers. The paucity of immunoglobulins contributes to the high risk of systemic infection. Very recent data on critical septic adults demonstrated that IgM enriched immunoglobulins reduce mortality. Available data about the role of IgM enriched immunoglobulins as adjuvant therapy in neonatal sepsis are still conflicting especially on VLBW infants that are the class of neonate more susceptible to infection. We provide a critical review on current literature.