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Association between haptoglobin genotype and coronary artery stenosis in patient with premature coronary artery disease

Yunying Wang, Wei Li, Kexu Sui, Qiyi Zhang, Xiaoying Ma

Background: Accumulating evidence implicates Haptoglobin (Hp) gene polymorphism as a potential risk predictor for Coronary Artery Disease (CAD). We explored the association of Hp polymorphism with premature CAD and its severity within 165 unrelated Chinese patients and 116 healthy controls using genotyping, biochemical parameters, and the Gensini scoring system. Levels of HP and IL-17 in plasma were determined by ELISA.

Results: The frequencies of Hp genotypes and Alleles, Hp levels and IL-17 levels were significantly different between CVD group and control group, and among the three subgroups. Hp2-2 was associated with the highest Gensini score but the lowest Hp concentrations. After adjustments for confounding parameters, the OR of premature CAD associated with Hp2-2 was 0.630 (95% CI 0.449-0.884; P<0.05). The Hp2-2 genotype was associated with an increase in coronary artery stenosis especially in group C (OR=2.319; 95% CI 1.278-4.209; P<0.05). Gensini score was associated with Hp and IL-17 levels when we considered the entire patients. r-values were 0.296 and 0.140, respectively (P<0.05).

Conclusions: Hp polymorphism is independently associated with increasing CAD severity. Hp and IL-17 may be biomarker of coronary artery stenosis. Further studies are warranted to study the role of Hp and IL-17 in the pathogenesis of CAD.