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Changes in the T-lymphocyte immune functions of patients with cervical cancer after surgery and their clinical significance

Li-Bo Li, Yi Yang, Yong Li, Han-Qun Zhang, Zhao-Peng Zheng, Yan-Ping Chen, Ying-Jie Nie

Objective: This study aimed to discuss changes in the T-lymphocyte immune functions of patients with cervical cancer after surgery and their clinical significance.

Methods: A total of 80 patients with cervical cancer who had undergone surgical treatment in our hospital from January 2014 to July 2017 were selected as the observation group. Additionally, 50 healthy women volunteers in the same time period were considered as the control group. T-lymphocyte-secreted cytokines and T-lymphocyte immune function indices were examined before and after surgery of all respondents. Detection results of the two groups before and after surgery were compared. The observation group was further divided into postoperative infection-free and postoperative infection groups according to the occurrence of postoperative infection. The T-lymphocyte-secreted cytokines and T-lymphocyte immune function indices of these two groups were compared.

Results: Interleukin (IL)-2, Tumor Necrosis Factor-α (TNF-α), Interferon-γ (IFN-γ), IL-2+CD4+, TNF-α +CD4+, and IFN-γ+CD4+ levels of the observation group were lower than those of the control group (P<0.05). According to postoperative detection results, IL-2, TNF-α, IFN-γ, IL-2+CD4+, TNF-α+CD4+, and IFN-γ+CD4+ of the observation group increased sharply compared with those before surgery (P<0.05). IL-2, TNF-α, IFN-γ, IL-2+CD4+, TNF-α+CD4+, and IFN-γ+CD4+ of the observation group after surgery are significantly higher than those of the control group (P<0.05). Different indices of the postoperative infection group were higher than those of the postoperative infection-free group (P<0.05).

Conclusions: The T-lymphocyte immune functions of patients with cervical cancer recovered after surgery, and the immunity of the postoperative infection group was further enhanced.