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Chronic Rhinosinusitis and Structural Remodeling

Philip M Muthoka

Rhinosinusitis is a significant health problem that affects both adults and children, and when it becomes chronic results in a unique disease burden. About 50% of the worldwide population suffer from rhinosinusitis at one time or another and 20% seek some form of medical assistance. Many of these people go on to develop chronic rhinosinusitis (CRS), such that the worldwide prevalence is 10% but can vary from 7% to 27% (1). CRS is currently defined as nasal and/or sinus symptoms that persist more than 12 weeks, and is confirmed by either endoscopy or computed tomography imaging.