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Clinical efficacy of weifuchun combined with retinoic acid on treatment of patients with PLGC and effect on expressions of gene Rb and C-erbB-2

Min Shu, Zhe Jiang, Yuanyuan Wang, Qinggong Yu

Objective: To investigate the clinical efficacy of weifuchun combined with retinoic acid on treatment of PLGC (Precancerous Lesion of Gastric Cancer) patients and effect on the expressions of gene Rb and CerbB-2.

Methods: A total of 126 patients of gastric mucosa chronic inflammation associated with dysplasia with or without gastric mucosal metaplasia who were confirmed by endoscopic biopsy and pathology were enrolled in this study, randomly divided into the treatment group (63 cases) and control group (63 cases). The patients in the treatment group received the basic treatment of chronic gastritis (omeprazole +sucralfate) and the test drugs (weifuchun+retinoic acid), and patients in the control group received the basic treatment of chronic gastritis. The expressions of Rb and C-erbB-2 before and after treatment were detected by immunohistochemical staining.

Results: The ORR of the treatment group was significantly higher than that of the control group after treatment; in the treatment group, the positive expression rate of Rb was significantly higher than that of the control group, while the positive expression rate of C-erbB-2 in the treatment group was significantly lower than that of the control group.

Conclusion: Weifuchun combined with retinoic acid has a therapeutic effect for Patients with PLGC; it may play its role by up-regulating tumor suppressor gene Rb and down-regulating cancer gene CerbB-2.