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Dapirolizumab pegol: A novel treatment of patients with SLE by inhibiting CD40L

Farnaz Fallah-Arani,

CD40 ligand (CD40L) has been described as one of the key players in regulating T cell, B cell and antigen-presenting cell activity. Pre-clinical evidence and phase 1 and 2 clinical studies with anti-CD40L antibodies, such as ruplizumab and toralizuamb suggest that CD40L blockade may be efficacious in the treatment of inflammatory and autoimmune conditions. However, clinical development of these antibodies was discontinued because of significant thromboembolic events, due to Fcmediated cross linking, resulting in platelet activation. UCB and Biogen have developed Dapirolizumab pegol (DZP) which comprises of Fab fragments with a high affinity for CD40L, conjugated to polyethylene glycol (PEG) scaffolding to deliver desired pharmacokinetic characteristics