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Dengue and doxycycline-experience in a tertiary care hospital in eastern India in the year 2017 - An initial report.

Boudhayan Bhattacharjee*, Subhayan Bhattacharya, Bikash Sardar, Pushkar Raj, Moumita Ghosh, Debajyoti Majumdar, Arindam Naskar, Manab Kumar Ghosh, Sudeshna Mallik, Bibhuti Sah

Dengue fever is an arthropod-borne viral haemorrhagic fever. Suspected dengue patients admitted in the of School of Tropical Medicine, Kolkata were taken as a case after considering inclusion and exclusion criteria. Aim of this study was to determine the effect of doxycycline in course and final outcome of dengue fever. Selected patients were subjected to history, examination, necessary investigations and then were managed according to NATIONAL VECTOR BORNE DISEASE CONTROL PROGRAMME (NVBDCP) guidelines. A total of 24 serology proven dengue patients were included and followed up. Two groups (twelve in each) were allocated by simple random sampling. Treatment group was given doxycycline and control group were given placebo. Age and sex profile were similar in both groups. 75% of patients in treatment group had no bleeding with no patients having major bleed; where in control group 25% of had major bleeding. Plasma leakage were less in treatment group (25%) as compared to control group (58.3%). Hemodynamic compromise was more in control group (16.7%) as compared to treatment group (8.30%). 41.70% of patients in treatment group had no thrombocytopenia in comparison to control group (16.70%). Also, only 8.30% of patients had platelets below 10,000/cmm in treatment group where it is 16.70% in control group. Platelet transfusion was necessary in 8.30% of treatment group patient in comparison to 16.70% of control group patients. Liver involvement in control group was more in comparison to treatment group. Control group has pancreatic involvement in 16.60% of patients; renal involvement in 8.30% of patients; cardiac involvement in 8.30% of patients. Whereas no pancreatic, renal or cardiac involvement were seen in treatment group. An initial report of this study showed significant reduction in complications of dengue fever in respect to different organ involvement when treated with doxycycline.