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Earlier Detection of Pregnancy with Serum Human Chorionic Gonadotropin Shows Excellent Prognostic Value in Gestation 4 Weeks after In Vitro Fertilization

Akiko Kawasaki, Hajime Okamoto, Naoki Kita, Yoko Ainoya, Atsushi Wada, Yukiko Wagatsuma, Toyomi Sato

Aim: To research whether the prognostic value of pregnancy outcome with a serum human chorionic gonadotropin (HCG) test is changed by 3 days earlier measurement in gestation 4 weeks after in vitro fertilization (IVF).

Methods: The study design is a retrospective analysis. Patients are women who underwent IVF in one institute. We investigated the difference in the prognostic value of serum HCG levels on day 16 and 19 from oocyte retrieval. Pregnancy outcomes are classified into biochemical pregnancy, miscarriage and ongoing pregnancy.

Results: In the serum HCG values on day 16, there was a significant difference among the three respective groups. In serum HCG values on day 19, there was a significant difference between the biochemical pregnancy group and miscarriage group, however there was no significant difference between the miscarriage group and ongoing pregnancy group. The AUC for prediction of ongoing pregnancy on day 16 was higher than the AUC on day 19.

Conclusion: The prognostic value of pregnancy outcome with serum HCG levels was decreased when the date of measurement was delayed only for 3 days.