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Effect of fexofenadine on peripheral blood mononuclear cell expression of HRH-1 and HRH-4 receptor

Emma Dumas

The histamine receptors HRH-1 and HRH-4 are expressed on peripheral blood mononuclear cells (PBMCs) and play a role in immune responses. Fexofenadine is an antihistamine drug that specifically targets HRH-1 receptors. In this study, we investigated the effect of fexofenadine on the expression of HRH-1 and HRH-4 receptors on PBMCs. PBMCs were isolated from healthy volunteers and treated with increasing concentrations of fexofenadine for 24 hours. The expression of HRH-1 and HRH-4 receptors on PBMCs was analysed by flow cytometry. Our results showed that fexofenadine treatment did not affect the expression of HRH-1 or HRH-4 receptors on PBMCs. This suggests that the antihistamine effects of fexofenadine on HRH-1 receptors do not alter the expression of other histamine receptors on PBMCs. In conclusion, fexofenadine specifically targets HRH-1 receptors without affecting the expression of HRH-4 receptors on PBMCs. This finding provides further understanding of the immunomodulatory effects of antihistamine drugs and may aid in the development of new treatments for allergic and inflammatory diseases.