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Effect of twelve meridian cordyceps correlated compounds on glycemic control in patients with type 2 diabetes mellitus: A before-after self-control study.

Jian Du1,2,3*, Yimeng Chen1,4, Zhiyun Cao1,2,3, Xiaoting Yang1, Xiaofang Wu2, Yang Yan2, Ruichen Chen5

Aim: The present study aimed to evaluate the effect of Twelve Meridian Cordyceps Correlated Compounds (M12CCC), a new functional food, on glycemic control in patients with Type 2 Diabetes Mellitus (T2DM). Methods: The subjects recruited 30 patients with T2DM aged 30-75 years from Outpatients completing 90d trial. The 30 cases received M12CCC 4.5g/d for orally three times a day (1.5g/bag in 100 mL hot water before 30 min of each meal) for consecutive 90 d. Their base-line value including fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and oral glucose tolerance test 2-hour plasma glucose (OGTT2hPG) and these indexes value after intervention for 30 d,60 d and 90 d was measured. Results: Excluded the base-line value of HbA1c <6.5% cases because of blood glucose are controlled stably generally. The base-line value of HbA1c is more than 6.5% in 23 cases which compared with that value after treatment for 90 d showed that HbA1c declined 0.5% (P=0.001). FPG of treatment for 30 d, 60 d and 90 d differently compared with the base-line value indicated that there were no significant differences (P =0.603, P =0.233 and P=0.783). However, OGTT2hPG of treatment for 30 d, 60 d and 90 d was markedly decreased compared with the baseline value (P=0.000, P =0.000 and P=0.005) with no time-dependent manner. Body composition including body weight, BMI, TG, TC, UA, Muscle mass, fat mass, bone mass, body fat percentage, waist-hip ratio and visceral fat were no significant differences between baseline and 90 days. Conclusion: M12CCC has a strong regulating effect on decreasing HbA1c and OGTT2hPG to poor glycemic control patients.