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Effects of neoadjuvant chemotherapy combined with cervical cancer radical surgery for the treatment of cervical cancer

Liyan Duan, Kequn Zhang, Yanqiu Wang, Jian Jin, Junyan Xie, Xiang Luo, Qiaozi Deng

Objective: To investigate and analyze the clinical efficacy of neoadjuvant chemotherapy combined with cervical cancer radical surgery for the treatment of cervical cancer.

Method: Sixty-four patients with cervical cancer who visited our hospital from January 2015 to December 2016 were randomly selected and randomly divided into observation (n=32) and control groups (n=32). The observation group was treated with neoadjuvant chemotherapy combined with cervical cancer radical surgery, and the control group was given only cervical cancer radical surgery. Clinical effects between patients in the two groups were compared.

Results: Intraoperative blood loss, lymph node metastasis rate, and incidence rate of positive vaginal margin in the observation group were significantly lesser than those in the control group (P<0.05). The clinical efficacy of patients in the observation group was significantly higher than that of the control group (P<0.05). After the observation group received treatment, lymphatic cysts were found in two patients, namely, edema of lower limb in one, and urinary retention in one; moreover, the incidence rate of complications was 12.5%. After the control group received treatment, lymphatic cysts were found in three patients, edema of lower limb in three, and urinary retention in two, and the incidence rate of complications was 25%. The incidence rate of complications was significantly lower in the observation group than in the control group (χ²=5.128, P<0.05).

Conclusion: Neoadjuvant chemotherapy combined with cervical cancer radical surgery show good clinical efficacy for treating cervical cancer, and because of the low incidence rate of complications, it has clinical application value.