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Efficacy and mechanism of action of atherosclerosis in patients with statins

Dan Chen, Ting Liu

Objective: To investigate the efficacy and mechanism of action studies of statins for patients with atherosclerosis.

Methods: 104 cases of atherosclerosis were selected from our hospital and randomly divided into control group, simvastatin group, pravastatin group, atorvastatin group according to the random number table. Determination of four groups of patients before treatment and triglyceride six months after total cholesterol, high density lipoprotein cholesterol and low-density lipoprotein cholesterol levels, while measuring their bilateral carotid artery intima-the thickness of the middle, Spectrophotometry using content in blood NO and nitric oxide synthase (NOS), porridge the maximum sample diameter and thickness of plaque and statistics patients experienced adverse reactions.

Results: Statin group before and after treatment in triglyrcerid (TG), total cholesterol (TC), and low density lipoproteincholoesterol (LDL-C) values show a downward trend, HDL-C showed a rise trend. Compared with the control group, the difference was statistically significant (P<0.05), while the interior was no significant difference (P>0.05) ; the overall efficacy in the statin group after treatment efficiency is over 95%, compared with the control group, there was statistically significant difference (P<0.05) ; the maximum diameter of the statin group with IMT and plaque before treatment difference was statistically significant (P<0.05), Elevated levels of serum NO and NOS, whereas no significant difference (P>0.05) between the groups. Follow-up results showed that statins safe and effective in the use of the process.

Conclusions: Statins is safe, effective and reliable for the treatment of atherosclerosis.