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Elevated serum levels of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) are associated with poor pulmonary thromboembolism (PTE) prognosis

Songul Ozyurt , Mevlut Karatas, Aziz Gumus , Bilge Kara , Halit Cinarka , Unal Sahin

Introduction: The prognostic role of SCUBE1 serum levels in PTE has best of our knowledge, not been previously investigated.

Materials and Methods: The study included 49 patients diagnosed as having acute PTE. This singlecentre prospective study was conducted between Jan 2015 and 2016.The diagnosis of PTE was reached through spiral angio computed thorax tomography. Serum SCUBE1 was measured on admission. Troponin-T, cardiac enzymes, echocardiography and simplified pulmonary embolism severity index (sPESI) of all the patients were recorded.

Findings: The mean age at diagnosis was 69.4 ± 13.4 y who are 20 male and 29 female patients. The mean serum SCUBE1 level in our study was 1.79 ± 0.24 ng/ml. The serum SCUBE1 level was significantly higher in the cases with high-risk sPESI than those with low-risk sPESI (18.00 ± 0.26 ng/ml and 17.75 ± 0.17 ng/ml (p=0.001), respectively). It was also shown that there was a significant correlation between the SCUBE1 and serum albumin levels (r=-0.501) and Red Cell Distribution Width (RDW) (r=0.301) and urea (r=0.296). None of the patients passed away during hospitalization and one-month follow-up.

Conclusion: SCUBE1 can be used for predicting in patients with PTE. However, further studies are essential, and in particular should include high-risk (massive) pulmonary embolism patients.