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Evaluation of antinociceptive potential of methanolic extract of different parts of Ehretia serrata Roxb and Ehretia obtusifolia in vivo

Zill-E-Huma, Abdur Rauf, Kiran Natasha, Naila Shah, Muhammad Ibrar, Barkatullah, Haroon Khan, Mohammad S. Mubarak, Aneela Maalik

Background: The antinociceptive potential study of different parts of Ehretia serrata Roxb and Ehretia obtusifolia are least explored till now. These plant parts are usually used as fodder and wood in Asia. The aim of this work was to find the antinociceptive effects of the methanolic extracts of leaves, fruits and stem barks of these plants in mice.

Methods: The antinoceceptive activity of methanolic extract of leaf, fruit, and stem bark of E. serrata and E. obtusifolia in mice was carried out by means of the hot plate method and by using diclofenac sodium as a standard. Twenty groups of 12 h starved mice were prepared where each group comprised of five mice only. While all these starved mice were allowed free access to clean water. In this study, both male and female Albino mice were used. Analgesiometer was used for this bio-essay.

Results: The results showed that the dose significantly (P<0.05) reduced the time spent in pain behaviour in all assessment times (0 min, 30 min and 60 min) hence indicating that the plant possesses antinociceptive potential.

Conclusion: It is confirmed through the findings that E. serrata and E. obtusifloia exhibit strong antinociceptive action in animal model of hot plate which needs verification in other paradigms too.