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Evaluation of osteopontn, c-telopeptide of type-I collagen and matrix metalloprotein in post- menopausal Egyptian women with osteoporosis

Azza M Abdu Allah, Shereen A. El Tarhouny, Seham A Khodeer, Inass M Taha

Introduction: Osteoporosis is a widespread age-related skeletal disorder characterized by bone loss, which increases skeletal fragility. This study was done to assess the relationship between CTX1, MMP and OPN levels and BMD in postmenopausal Egyptian women.

Patient and Methods: This search was made on 173 postmenopausal female. MMP-3, OPN and CTX I was done by ELISA. BMD was carried out by dual energy X-ray absorptiometry. According to BMD; they were divided into 3 groups; osteopenia, osteoporosis and control groups.

Results: CTX1, OPN and MMP-3 levels were significantly greater in osteoporosis and osteopenia than the control group (P<0.001). In osteoporosis, negative correlations between OPN, calcium and BMD, were found as well as positive correlations between OPN, MMP-3 and CTX-I. By using ROC curve, the sensitivities of both OPN and MMP-3 were equal (93%) and specificities were 100% and 84% respectively.

Conclusion: CTX1, OPN and MMP3 were significantly increased in postmenopausal women with osteoporosis suggesting their role in bone turnover. The preserving of normal BMD is a challenge for postmenopausal women to prevent bone disabilities. So, further studies are recommended to use CTX1, OPN and MMP -3 as a regular monitoring system-being sensitive and easy to measure- for early noninvasive detection of osteoporosis in postmenopausal women.