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Examination of cytokines in the intraocular fluids in Clinic

Yong Tao

Examination of cytokines in the intraocular fluids in Clinic: Examinations of cytokines in the intraocular fluids are commonly used in research. In our clinic, it has been used to help clinical doctors to make a diagnosis of uveitis and vitreoretinal diseases in the early stage. In addtion, it provide benefits for experimental treatment. For instance, by measurement of the IL-10/IL-6, one may make a presumed diagnosis of intraocular lymphona. By monitoring the intraocular IL-8, one may judge the level of intraocular inflammation and decide whether the anti-viral drug for intravitreal injection to treat cytomegalovirus retinitis/acute retinal necrosis should be changed or not. Similarly, measurement of IL-8 in the aqueous humor help to judge experimental treatment to use intravitreal injection of anti-fungal/antibiotics for management of endophthalmitis is successful or fail. Measurement of the intraocular VEGFA is somewhat privotal before intravitreal injection of anti-VEGF drugs such as ranicizumab for diabetic macular edema/ retinal vein occulsion/ choroidal neovascularization. Before intravitreal injection of triamcinolone or ozurdex is performed, examination of intraocular inflammatory cytokines is helpful. Therefore, precision treatment of uveitis and vitreoretinal diseases get benefits from examination of cytokines in the intraocular fluid.