Абстрактный

Extending neuroendocrinology: strain, sexuality, and physiological and behavioural control

Benjamin parker desouza*

The definition of "neuroendocrinology" has been expanded to include the reciprocal communication between the brain and body via hormonal and neural pathways as a result of the identification of steroid hormone receptors in brain areas that mediate every aspect of brain function. Because it perceives and judges what is hazardous and determines the behavioural and physiological reactions to the stressor, the brain is the primary organ of stress and adaptation to stress. In response to stress, the adult and developing brain exhibits remarkable structural and functional plasticity, including synapse turnover, dendritic remodelling, and neuronal replacement. Stress leads to an imbalance in the neural circuitry that supports cognition, judgment, anxiety, and mood, which can change how these behaviours and behavioural states are expressed. Furthermore, negative early experiences interact with specific gene alleles to produce long-lasting effects on the body and brain over the course of a lifetime via epigenetic mechanisms. Although prevention is crucial, there is hope for therapies that consider how the brain and body interact thanks to the brain's plasticity.