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In vivo evaluation of wound healing activity of cinnamon oil loaded hydrogel

Amira Nour

Extraction of Cinnamomum verum Essential Oil (CEO) was implemented using hydro distillation method. The antimicrobial activity of CEO was evaluated against Candida albicans, gram negative bacteria namely: Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis and gram positive bacteria namely: Methicillin Resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus. The maximum Inhibition Zone Diameters (IZD) of CEO were against S. aureus and MRSA (24,83 ± 1.76 and 27.97 ± 1.18 mm), respectively. Further evaluation was done using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) which reported the highest effect against MRSA (29.20 ± 2.82, 112.03 ± 2.05 μg/mL), respectively. GC-MS and FTIR analyses proved that the major compound of CEO was cinnamaldehyde. Experimentally induced wounds were implicated in rats. Assessment of wound healing using wound contraction percentage and histopathological evaluation showed significantly high wound contraction percentage, reepithelialization and collagen deposition in the CEO hydrogel treated group in relation to the other tested groups.