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Inflammatory Coagulopathy in Acute Sepsis

Debra Donnelly

A severe clinical disease with an elevated mortality rate globally, sepsis is defined by the coexistence of infection and host inflammation. Disseminated intravascular coagulation (DIC) is a diffusely activated coagulation system caused by the consumption of several clotting components in severe illness. When DIC is present, a greater death rate is predicted. Therapeutic therapies can be created if it is known how inflammation and diffuse thrombosis are related. The Coagulopathy of Acute Sepsis is a dynamic process that depends on both the time and the severity of the illness. Compared to traditional tests, whole blood coagulation testing may offer more therapeutically valuable information. Sepsis inhibits the natural anticoagulants that control thrombosis. When systemic inflammation and hyper coagulopathy are present, patients may benefit from coagulation system regulation. Anticoagulant medication administered at the right time may eventually reduce the prevalence of multisystem organ dysfunction (MODS).