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Molecular dynamics simulations reveal a common conformation in the β chainconstant region in T cell receptor activation

Josephine Alba

The adaptive immune response is one of the most important systems of defense against pathogens. In this contest, the ability of the CD8+ Cytotoxic T Lymphocytes (CTLs) to recognize a wide number of foreign antigens represents a strong defense against diseases. The T cells response is regulated by T Cell Receptor (TCR) activation, which may occur following the epitope recognition (p), mediated by the Major Histocompatibility Complex (MHC). Experimental studies have suggested that conformational changes involving the constant region of the TCR α chain and of the CD3 complex are responsible for the