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Olfactory Nerve Regeneration Time Period after the Damage

Hashem Shemshadi*

As the nanopartcles stmulate the olfactory mucosa, an electrochemical initaton will start. The message as an a?erent stmulus passes through the ethmoid bone cribriform plate for delivering such memorandum toward the central nervous system. Thus, the sense of smell will be detected and translated to a pleasant and or non- pleasant memory narratIon.
Head injures such as a coup - counter coup in a blunt trauma, central nervous system`s infectons such viral infecton (COVID-19), bacterial meningits, tumors and surgical manipulatons such as nasal operatons, may be considered as some common cause of olfactory nerve damages. Regeneraton of olfactory nerve afer the damages due to the aforementoned causes depends on the origin and the degrees of the damage. Some tough injuries may even result complete and/or permanent loss of smell (anosmia). Some complete losses may gradually regenerate from anosmia to hyposmia and in follow leading into complete recovery of normal smell functoning (norm Osmia).
We did examine olfactory nerve damage in patents who underwent open rhinoplasty in the past. The research report was issued in November 2008 in PubMed. We tried to investgate "when" the olfactory functon recovers to its normal preoperatve levels. In this pre and post operatve research design, 40 of 65 esthetcs open rhinoplasty candidates with equal gender distributon, who met the inclusion criteria, were assessed. Their olfactory functon using the Smell Identfcaton Test (SIT) by using 40 culturally familiar odors in snifng botles. All the patents were evaluated for the SIT scores preoperatvely and postoperatvely (at week 1, week 6, and month 6). At postoperatve week one, 87.5% of the patents had anosmia. At postoperatve week six, 85% of the subjects experienced mild to moderate degrees of hyposmia. At the six months postoperatve, all patents` olfactory functon reverted to their preoperatve levels. A repeated ANOVA was indicatve of signifcant di?erences in the olfactory functon at the above-mentoned di?erent tme points. According to our post hoc Benfronney, the preoperatve scores had a signifcant di?erence with those at postoperatve week 1, week 6, but not with the ones at month 6. Thus, the primary cosmetc open rhinoplasty may be accompanied by some degrees of postoperatve olfactory dysfuncton. Patents need a tme interval of 6 weeks to 6 months to fully recover from surgical manipulaton and respectve edema into their preoperatve baseline olfactory functon.