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Pharmacology 2018: Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

Eun-Young Yun

Obesity is increasingly becoming a public ill health worldwide . it's caused by an energy imbalance characterized by high energy intake relative to energy expenditure, also as established risk factors like type 2 diabetes, disorder, atherosclerosis, stroke, and Dyslipidemia . within the central Nervous System (CNS), the hypothalamus plays a critical role because the primary regulator of feeding behaviour and energy homeostasis by regulating appetite-related neuropeptides and neuronal excitations. Dysfunction of the hypothalamus results in energy imbalance, which has been recognized as a possible pathogenic mechanism of obesity.