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Plant Expressed Vaccines Produce A Novel Synergistic Response Upon Co-delivery.

Mary D. Pardhe

We have previously shown that plant-made recombinant immune complex (RIC) vaccines that consist of an antibody fused to a desired antigen and containing an antibody-specific epitope tag are a robust platform to improve the immunogenicity of weak antigens. In this study, we altered the antigen fusion site on the RIC platform to accommodate an N-terminal fusion to the IgG heavy chain (N-RIC) with a resulting 40% improvement in RIC expression over the normal C-terminal fusion (C-RIC).