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Prenatal ultrasound diagnosis of VACTERL syndrome and partial caudal regression syndrome

Qing Li, Na Liang, Qiu Zhang, Li Li

Objective: To explore prenatal ultrasound diagnosis of VACTERL syndrome and partial caudal regression syndrome.

Methods: 60 patients with VACTERL syndrome and partial caudal regression syndrome treated in our hospital during September 2011 to December 2013 were retrospectively analysed. The prenatal sonographic of patient was analysed taking the postpartum result as a standard.

Results: Prenatal ultrasonic examination illustrated that there were 18 cases of anal atresia (30.00%), 26 cases of spine abnormalities (43.33%), 24 cases of malformation of upper limb (40.00%), 23 cases of malformation of lower limb (38.33%), 34 cases of renal malformation (56.67%), 46 cases of cardiac malformation (76.67%), 18 cases of tracheoesophageal fistula or esophageal atresia (30.00%), 9 cases of double umbilical arteries (15.00%). In the patients with VACTERL syndrome, there were 41 cases of 3 comprehensive deformities (68.33%), 15 cases of 4 comprehensive deformities (25.00%), 4 cases of 5 comprehensive deformities (6.67%), without 6 comprehensive deformities. There were 28 cases (46.67%) of patients with partial caudal regression syndrome, including 18 cases of 2 comprehensive deformities (30.00%), 8 cases of 3 comprehensive deformities (13.33%), 2 cases of 4 comprehensive deformities (3.33%). There were 31 cases of patients with other malformations (51.67%), with 23 cases of single umbilical artery (38.33%). All the ultrasonic examination results were in accordance with postpartum results, with no significant difference (p>0.05).

Conclusions: Prenatal ultrasonic diagnosis of VACTERL syndrome and partial caudal regression syndrome was of great value, which could guide obstetric treatment and was worthy of promotion clinically.