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Prevalence and factors associated with dyslipidemia in otherwise healthy Asian Indian American adolescents.

Naveen Mehrotra, Anna Petrova

Introduction: This study was designed to evaluate results of lipid screening of American Asian Indian adolescents in a primary care setting to define prevalence and factors associated with development of dyslipidemias. Methods: An administrative database was used to select American Asian Indian adolescents (10-20 years) whose lipid profiles were measured during 2013. Demographics, obesity/overweight, and summary of lipid measures defined as acceptable, borderline, and high were analyzed. Dyslipidemia was defined as combined if triglyceride to the high-density lipoprotein cholesterol ratio was more than 3 and multifactorial if total cholesterol was 200 mg/dL or more and/or low-density lipoprotein cholesterol was 130 mg/dL or more. Statistical analysis included analysis of variance, chi-square, and multivariate regression. Data presented as proportion, mean and odd ratios (OR) with a 95% confidence interval (95% CI). Results: Of 244 American Asian Indian adolescents studied (55.7% males), dyslipidemia borderline and high was classified in 151 (61.9%), and between 75 adolescents with high dyslipidemia, 32 (42.7%) had combined and 20 (26.7%) multifactorial dyslipidemia. The increased risk for overweight and obesity was associated with high dyslipidemia (OR 1.48, 95%CI 1.03, 2.11) and (OR 1.78, 95%CI 1.10, 2.87), respectively. Moreover, 65.5% of patients with combined and 55% with multifactorial were overweight or obese. Conclusions: Lipid profiles were abnormal in most American Asian Indian adolescents, including one-third with high dyslipidemia, defined as combined and/or multifactorial, and significantly associated with overweight/obesity. Study findings allow for better understanding of the prevalence of dyslipidemia in this population, and therefore, increase parental and pediatricians’ responsiveness to reduce the risk for further progression to cardio-vascular diseases in Asian Indian adults.