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Principles and Implications of Proteomics in Clinical Therapy

Camden Heather

Proteomics is the study of dynamic protein expression, post-translational modifications, cellular and sub-cellular protein distribution, and protein-protein interactions. Advances in proteomic technology now offer potential for proteomic profiling to become standard practice in the clinical laboratory. A number of technical obstacles remain before routine proteomic analysis can be achieved in the clinic. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. Biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Clinical applications of proteomics involve the use of proteomic technologies at the bedside. The analysis of human cancer as a model for how proteomics can have an impact is now employing several new technologies. These include early detection, therapeutic targeting and finally, patient-tailored therapy.