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Recent synthetic and medicinal perspectives of pyrroles: An overview.

Ramandeep Kaur1, Vibhuti Rani1, Vikrant Abbot1, Yagyesh Kapoor2, Debabrata Konar3, Kapil Kumar1,2,3*

Pyrrole is a privileged scaffold with assorted nature of biological activities. Many active compounds have been developed by amalgamation of different pharmacophores in a pyrrole ring system. Pyrroles are an active component of complex macrocycles, including the porphyrins of heme, chlorins, bacteriochlorins, chlorophyll, porphyrinogens. Pyrrole and its derivatives are widely used as intermediates in synthesis of pharmaceuticals, agrochemicals, dyes, photographic chemicals, perfumes and other organic compounds. The pyrrole skeleton is an imperative structural framework found in extensive range of biologically active natural products and pharmaceutically active molecules. They are an element of polymers, indigoid dyes and large aromatic rings. Pyrroles are utilized as a catalyst for polymerization process, corrosion inhibitor, preservative, solvent for resins and terpenes. It is functional in various metallurgical process, luminescence chemistry, spectrochemical analysis and transition metal complex catalyst for uniform polymerization. Furthermore, some of the compounds are useful intermediates in the synthesis of biologically important naturally occurring alkaloids and synthetic heterocyclic derivatives. In this review, attempts are made to disclose various tactical approaches to synthesize pyrrole and its derivatives. The structure activity relationship studies have been discussed along with their pharmacological applications.