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Role of Rock 1 protein in non-small cell lung cancer

Shao-hua Yan, Hai-Cheng Gao, He-yu Meng, Long Cheng, Lv Zhe, Guo-shen Cao, Wei-qun Yan, Hua Xin

The effects of Rock 1 in non-small cell lung cancer and the relationship between Rock 1 and non-small cell lung cancer were investigated in this study. Sixty cases of non-small cell lung cancer were investigated for the relationship between Rock 1 and non-small cell lung cancer. Expression of Rock 1 in non-small cell lung cancer was detected by histochemical staining and Real-time PCR. All the sixty cases had been diagnosed as non-small lung cancer by CT and HE staining. The expression of Rock 1 in nonsmall cell lung cancer was significantly higher than the adjacent tissues (p<0.05). Positive expression of Rock 1 was 73.33% in 60 cases. Among them, Positive expression of Rock 1 was 71.79% in squamous cell carcinoma of 39 cases. Positive expression of Rock 1 was 76.19% in adenocarcinoma of 21 cases. The expression of Rock1 may be positively related to the lung cancer, suggesting that Rock 1 play an important role in non-small cell lung cancer.