Абстрактный

Routine screening of SARS CoV-2 in the pregnant women in Primary Health Care

Dewi Setiawati

Asia  has become one of  the epicenter of coronavirus pandemic. It seems that asymptomatic population may contribute importantly to the spread of the disease. Transmission from asymptomatic pregnant woman  needs to be tested in large scale, but  In primary health care without facilities for RT PCR SARS CoV-2, antibodies and the level of Wbc and lymphocytes may become as alternative test. Objective: To assess the prevalence of SARS CoV-2 infection in matic asymtomatic pregnant woman in primary health care. Methods This was a cross-sectional study was performed. Pregnant women admitted at policlic Obstetrics & Gynecology of  Wirahusada Medical Center for antenatal care, between November 1st  and December 31, 2020. A total of 142 pregnant woman without symproms were tested for  rapid antibody for SARS CoV-2 and checked for routine hematology during the study period. Asymtomatic pregnant woman with rapid antibody positif  then cronfirmed  with RT-PCR for SARS CoV-2. Results: From 142 pregnant women who underwent screening, there were 11 (7.7%) who were positive (IgG / IgM, while the negative  were 131 (92.3%). 11 asymptomatic  pregnant woman was confirmed positive RT-PCR for SARS CoV-2 in secondary Health center (hospital). There were differences in the mean Wbc levels in the group of asymptomatic  pregnant women with positive SARS CoV-2 antibodies (3742.73) compared to non-reactive  (9122.48), where the mean leukocyte levels were <4000 in subjects with positive SARS CoV-2 (p = 0.001). There was a difference in the mean lymphocyte levels in the group of pregnant women with positive SARS CoV-2 rapid antibody (12.7) compared to non-reactive (24.3), where the mean lymphocyte levels were lower in subjects with positive SARS CoV-2 Rapid IgG / IgM pregnant women ( p = 0.001). There was no difference in the mean lymphocyte levels in the group of pregnant women with positive SARS CoV-2 antibodies (11.06) compared to non-reactive pregnant women (11,36), where the mean Hb levels were not different in subjects with positive SARS CoV-2Rapid IgG / IgM pregnant women (p = 0.551). There was no difference in the mean lymphocyte levels in the group of pregnant women with positive SARS CoV-2 positive antibodies (280,454) compared to non-reactive (300,778), where the mean pletelet levels were not different in subjects with positive SARS CoV-2 Rapid IgG / IgM pregnant women (p = 0.346 ) Conclusion ; In our study Wbc levels and the percentage of lymphocytes were significantly lower in subjects of asymptomatic pregnant women with positive SARS CoV-2  antibodies than  non-reactive pregnant women. In primary health care without facilities for RT PCR SARS CoV-2, antibodies and the level of Wbc and lymphocytes can be used as alternative for Routine screening in asymptomatic pregnant woman.