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Spectrophotometric determination of cisplatin, carboplatin and oxaliplatin in pure and injectable dosage forms

Muhammad Munawar Hayat, Muhammad Sohail, Muhammad Ashraf

Objective: A simple and reproducible spectrophotometric method was developed for the estimation of cisplatin, carboplatin and oxaliplatin in pure and injectable dosage forms. Method: The method is based on the reaction of platinum drug with 1,10-phenanthrolene in the presence of ferric chloride, which formed a red coloured complex that exhibited maximum absorption at 510 nm. The reaction is selective for platinum based drugs and obeys the Beer’s law for cisplatin from 0.25-6.0 μg, carboplatin 7.5-180 μg and oxaliplatin 0.5-12.0 μg. The accuracy of the developed method for cisplatin, carboplatin and oxaliplatin was 98.6%, 100.3% and 101.1%, whereas RSD (%) is of 1.1, 1.3 and 1.8, respectively. Result: The standardization and validation of analytic method was evaluated by the parameters like linearity, accuracy, precision and sensitivity. Conclusion: The method is useful for the determination of these drugs in pure and dosage forms.