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Study on difference of peripheral serum SP-D, anti-MDA5, IL-6 and TNF-α in CTD-ILD patients

Junli Wang, Yansheng Wang, Bing Han, Jian Xu, Xiaoli Li, Yan Rong, Dandan Zhang

Objective: To investigate the clinical value of peripheral serum levels of Surfactant Protein D (SP-D), anti-melanoma differentiation-associated gene 5 (MDA5), Insulation (IL-6) and Tumor Necrosis Factor (TNF-α) in the prognosis of the degree of Connective Tissue Disease combined with Interstitial Lung Disease (CTD-ILD).

Methods: 339 CTD-ILD patients, 184 CTD patients and 64 healthy volunteers in our hospital from January 2010 to December 2015 were enrolled into the study. The clinical symptoms, the test of High Resolution CT (HRCT) and lung function of all patients were detected and compared between the CTDILD and CTD patients. The serum levels of SP-D, anti-MDA5, IL-6, TNF-α were detected by ELISA among the three groups.

Results: The mean serum levels of SP-D, anti-MDA5, IL-6, TNF-α of CTD-ILD patients and CTD patients were both higher than the control group (P<0.05); and the mean serum levels of SP-D, anti- MDA5, IL-6 of CTD-ILD patients was higher than CTD patients (P<0.05). The mean level of SP-D of CTD-ILD patients with pant was higher than the patients without pant (P<0.05); the mean level of anti MDA5 of CTD-ILD patients with rash was higher than the patients without rash (P<0.05); the mean level of TNF-α of CTD-ILD patients with atony or cough was higher than the patients without atony or cough (P<0.05). The serum levels of SP-D, anti-MDA5, IL-6, TNF-α in CTD-ILD patients were related to the degree of pulmonary ventilation disorder and pulmonary diffuse dysfunction.

Conclusion: The detection of SP-D, anti-MDA5, IL-6, TNF-α of CTD-ILD patients could be helpful to diagnose the degree of connective tissue disease combined with interstitial lung disease.