Абстрактный

Systolic Blood Pressure and fluid state during the Peridialytic and Interdialytic period

Melanie Schoutteten

Objectives: Low systolic blood pressure (BP) and fluid overload (FO) are associated with the highest mortality risk in haemodialysis (HD) patients, however only assessed during the peridialytic period. The aim of this study was to evaluate BP and fluid status (FS) during the interdialytic period. Methods: In this cross-sectional two-centre study, BP and FS were measured during a mid-week HD session and at home during the interdialytic period. Systolic hypertension was defined as > 140mmHg, systolic hypotension < 90mmHg. FS was assessed using the body composition monitor and categorized as normal [FO/extracellular volume (ECW) < 6% or > -6%], fluid depleted (FO/ECW≤ -6%), or fluid overloaded (FO/ECW ≥ 6%). Results: A total of 68 HD patients were enrolled, mean age was 70.8 years. The prevalence of interdialytic systolic hypotension was 16.1%, with 33.3% being fluid depleted and 20% FO. Only 2.9% of all subjects had postdialytic systolic hypotension, all of them had a normal FS. Prevalence of interdialytic systolic hypertension was 38.7%, of which 33.3% was FO and 8.3% was fluid depleted. Interdialytic systolic BP was not associated with postdialytic BP. Overall, 32.1% of the subjects with postdialytic normal FS developed interdialytic FO. Conclusion: Home measurements showed a higher prevalence of interdialytic systolic hypotension and FO compared to postdialytic measurements. Interdialytic systolic BP was not correlated to interdialytic nor postdialytic FS. Home measurements of BP and FS during the interdialytic period provide valuable information to the haemodynamic profile of HD patients and might be detected more easily by remote monitoring techniques in the near future.