Абстрактный

The Cbfβ/Runx1 complex is important for the articular cartilage integrity

Xiangguo Che

Osteoarthritis (OA), a leading age-related disease in society, still lacks a clear molecular mechanism. Here, we explored in vivo role of core binding factor β (Cbfβ) in OA by generating articular cartilagespecific Cbfβ-deleted mice (Cbfβâ– ³ac/â– ³ac) using Gdf5 promoter-driven Cre mice. OA was induced through destabilization of the medial meniscus (DMM) surgery in 12-week-old male mice. At 8 weeks after surgery, OA phenotypes were more accelerated in Cbfβâ– ³ ac/â– ³ ac mice than wild type (WT) mice with increased expression of Mmp13 and decreased expression of Type II collagen. Interestingly, the expression of Cbfβ was reduced during aging as determined by immunohistochemisty. Furthermore at 5 months of age Cbfβâ– ³ac/â– ³ac mice, but not in WT, exhibited OA naturally without developmental defects in joint and skeletal tissue formation.