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The effect of clopidogrel combined with aspirin on myocardial enzyme, neurohumour and inflammation stress index in patients with myocardial infarction

Wang Wei, Wang Zhen

Objective: To discuss the clinical effect of clopidogrel combined with aspirin on myocardial enzyme index, neurohumour index and inflammation stress index in patients with Myocardial Infarction (MI).

Methods: We analysed 215 MI patients treated in our hospital from July 2016 to June 2017. 103 MI patients in the control group were treated with aspirin, and 112 MI patients in the observed group were treated with clopidogrel combined with aspirin. The basic clinical data, the results of the lab test, cardiac troponin I (cTn I), Creatine kinase-MB (CK-MB), Noradrenaline (NE), Angiotensin II (AngII), N-terminal pronatriuretic peptide (NT-proBNP), tumor necrosis factor-α (TNF-α), Interleukin 6 (IL-6) and Superoxide Dismutase (SOD) were detected and compared between the two groups.

Results: After treatment for 2 d, the plate aggregation rate induced by ADP 10 μmol/l or 20 μmol/l of patients in the observed group were respectively (7.65 ± 1.08%) with (8.74 ± 1.21%), which were obviously lower than the pre- treatment (P<0.05). The mean serum levels of cTnI and CK-MB were respectively (0.031 ± 0.002 ng/ml) and (19.84 ± 15.76 IU/ml) in the observed group, which were lower than the control group and pre-treatment (P<0.05). Besides, the mean serum levels of NE, AngII, NTproBNP, TNF-α, IL-6 in the observed group were all lower than the control group and pre- treatment (P<0.05); but the mean serum level of SOD in the observed group was higher than the control group and pre-treatment (P<0.05).

Conclusion: The application of clopidogrel combined with aspirin could be conducive to protect the myocardial cells, inhibit the myocardial enzyme, improve the neurohumour index, and remit the inflammation and stress reaction.