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The effect of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients

Hui-Liang Zhang, Li-Geng Li, Qing-hai Kong, Cheng Luo, Zhi-jie Feng, Hong Zhang, Jun-sheng Liang

Objective: We compared the correlation between serum Vascular Endothelial Growth Factor (VEGF) with D-Dimer, fibrinogen and thromboelastogram in order to investigate the effects of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients.

Methods: 68 elderly fracture patients that had undergone surgery were divided into two groups according to whether they were diagnosed with deep venous thrombosis in the perioperative period or not. We used the ELISA assay to detect the VEGF, D-Dimer and fibrinogen levels before the operation and 1 d, 5 d and 10 d post-operation. Thromboelastogram of patients before operation and after operation were recorded and further statistical analysis was conducted.

Results: The serum VEGF levels in the thrombosis group and non-thrombosis group both increased first and then decreased post-operation. After the operation at each of the different time points, the thrombosis group showed significant higher levels of serum VEGF compared to the non-thrombosis group (p<0.05). Serum VEGF levels in the thrombosis group increased significantly after operation and its peak level was higher than that of the non-thrombosis group. In addition, VEGF levels in the thrombosis group after the operation were positively correlated with the D-Dimer and fibrinogen content (R²=0.892, p<0.05; R²=0.921, p<0.05). However, for non-thrombosis group, the positive correlations between VEGF levels and the content of D-Dimer and fibrinogen were relatively weak (R²=0.634, p<0.05; R²=0.611, p<0.05).

Conclusion: VEGF levels have a certain relationship with the D-Dimer and fibrinogen content in the formation of deep venous thrombosis in elderly patients with fracture. This relationship indicates the changing of blood coagulation state and fibrinolysis process in the formation of deep venous thrombosis. The up-regulated expression of VEGF, to some extent, will guide the treatment process and prognosis of deep venous thrombosis.