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The efficacy of modified neutrophil alkaline phosphatase score, serum IL-6, IL-18 and CC16 levels on the prognosis of moderate and severe COPD patients

Jinbiao Zhang, Rongqin Dai, Wenyan Zhai, Nana Feng, Jiajing Lin

Objective: Our objective is to analyse the efficacy of modified Neutrophil Alkaline Phosphatase (NAP) score, serum Interleukin-6 (IL-6), IL-18 and human Clara cell secretory 16-kD protein (CC16) on the prognosis of moderate and severe Chronic Obstructive Pulmonary Disease (COPD) patients, which provides a reference to predict the prognosis of COPD patients.

Methods: 182 moderate and severe COPD patients admitted in our hospital during April 2012 to April 2015 were included in the observation group, and 150 healthy people were included in the control group for prospective analysis. Serum IL-6, IL-18 and CC16 levels were detected and the differences were analysed. Pearson’s correlation analysis was used to analyse the correlation of modified NAP score, serum IL-6, IL-18 and CC16 levels with pulmonary function, 2 y acute exacerbation times and 6 min walk distance in moderate and severe COPD patients (P<0.05).

Results: The serum IL-6 and IL-18 in the observation group were higher than the control group, and CC16 was lower than the control group, which were statistically significant (P<0.05). In the observation group, NAP score was normal in 104 patients and abnormal in 78 patients, the second day serum IL-6, IL-18 and CC16 were statistically different between patients with normal and abnormal NAP scores (P<0.05). Pearson’s correlation analysis showed that NAP score, IL-6 and IL-18 were positively correlated with the 2 y acute exacerbation times, and negatively correlated with FEV1, FEV1/FVC and 6 min walk distance. CC16 was negatively correlated with the 2 y acute exacerbation times, and positively correlated with FEV1, FEV1/FVC and 6 min walk distance (P<0.05).

Conclusion: Modified NAP score, serum IL-6, IL-18 and CC16 levels are closely correlated to the prognosis of moderate and severe COPD patients. Evaluation of the patient prognosis and actively intervention based on this can improve the life quality of patients.