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The expression difference of CEA, CA19-9, CA72-4 and CA125 in patients with different staging of gastric cancer and the relationship with metastasis and recurrence

Wang Hongzhi, You Yina

Objective: To analyse the expression difference of Carcino-Embryonic Antigen (CEA), Carbohydrate Antigen 72-4 (CA72-4), CA19-9, and CA125 in patients with different staging of Gastric Cancer (GC) and the relationship with metastasis and recurrence.

Methods: 284 cases of GC patients with surgery were selected from July 2013 to June 2014 in our hospital. After follower-up of 3 y, the metastasis and recurrence of GC patients was observed. And the expressions of CEA, CA19-9, CA72-4 and CA125 antigens in GC patients with different staging were measured. The relationship of CEA, CA19-9, CA72-4 and CA125 with metastasis and recurrence was analysed.

Results: The positive expression rates and the mean serum levels of CEA, CA19-9, CA72-4 and CA125 in T3/T4 staging GC patients were both higher than T1/T2 staging GC patients (P<0.05). And the positive expression rates and the mean serum levels of CEA, CA19-9, CA72-4 and CA125 antigens in T1/T2/T3 patients after surgery for 3 months were decreased than before surgery (P<0.05). After followed-up of 3 y, the positive expression rates of CEA, CA19-9, CA72-4 and CA125 antigens of patients with metastasis and recurrence before surgery were higher than patients without metastasis and recurrence (P<0.05).

Conclusion: The expressions of CEA, CA19-9, CA72-4 and CA125 antigens in patients with gastric cancer could be related with different staging, which would be the reference index for the diagnosis and prognosis of gastric cancer.