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The International Debate on Synthesis and Characterization of Smart Hydrogels Containing Graphene Nanosheets and Magnetic Nanoparticles for Drug Delivery Applications

Azadeh Tohidi a

 Hydrogel -based nanocomposites are relatively a new class of materials that have attracted great attention s in medical science s due to their superior physical and biologic al properties including high amount of water preservation, high drug -loading ability, biocompatibility, and similar structure to extracellular matrix (ECM) The aim of this study is to develop sensitive hydrogels based on Pluronic -chitosan/graphene nanosheets / magnetic nanoparticles for drug delivery into cancerous cells. The morphology, physical and chemical properties of the hydrogel-based nanocomposites were characterized by TEM /SEM, FTIR, VSM, DLS, and XRD techniques. Based on the TEM images, particle size of spherical Fe3O4 nanoparticles formed via a wet-chemical precipitation method is about 60 nm, confirming the particle size distribution observed through DLS results (66 nm). Additionally, porous structure of the nanocomposites with pore sizes about 150-180 µm is clear in the SEM micrographs. Drug release studies of alga extraction, which is known as an anti-cancer drug, also exhibit ed that mechanism of drug release belongs to a zero-order kinetics, and only 35% of the drug released during a 7-day period. As a result, the as-developed hydrogel nanocomposites can be introduced as an appropriate substrate for controllable drug delivery into cancerous cells.