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The role of hydrophilic porphyrin-[C60] fulleropyrrolidine dyads as nano-assisted photosensitizers towards cancer photo dynamic therapy (PDT)

Devashish Sengupta

 Nanoparticles are non-immunogenic and fail to elicit any immune response when introduced into the body’s circulatory system, which could otherwise lead to severe consequences like shutting off or blockage of the circulatory system. However, strong functionalization of nanoparticles like fullerenes with supramolecular photosensitizers (PS) can solve the problem and help develop nano-assisted PS with efficient applications in cancer photodynamic therapy (PDT). Hydrophilic porphyrinfulleropyrrolidine dyads of various topologies, consisting of meso- substituted pyridinium derivatives, covalently-linked to a fulleropyrrolidine, have shown selective cytotoxic action towards ovarian cancer cells.