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Therapeutic drug monitoring strategies and guidelines.

Chatelut Jones

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring certain drugs at specified intervals to maintain constant concentrations in a patient's bloodstream, thereby optimizing individual dosing regimens. Primarily to monitor drugs with narrow therapeutic ranges, drugs with highly variable pharmacokinetics, drugs with difficult to monitor target concentrations, and drugs that are therapeutic and known to cause unwanted effects used for The process of TDM is based on the assumption that there is a definable relationship between dose and plasma or blood drug concentration, and between concentration and therapeutic effect. TDM begins with the initial prescription of a drug and involves determining an initial dosing regimen appropriate to clinical status and patient characteristics such as age, weight, organ function, and concomitant medications.