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Urinary MCP-1 as a prognostic biomarker in diabetic nephropathy patients: A systematic review and meta-analysis.

Pingali Usha Rani, Mekala Padmaja, Mohammed Abid Ali, Imran Khan

Aim: To find a correlation between urinary MCP-1 and diabetic nephropathy severity to establish urinary MCP-1 as a potential biomarker in diabetic nephropathy for prognosis.

Methods: A systematic search was conducted to collect and analyze all studies published from year 1993 till 2021; that investigated the association between inflammatory cytokine urinary MCP-1 and diabetic nephropathy using the key words, ‘Urinary Monocyte Chemoattractant Protein-1 in Diabetic Nephropathy’. The included studies were extracted from PubMed, Science Direct and Cochrane databases.

Results: From the data searched in the electronic databases, a total of 588 articles were reviewed. Most of the studies did not meet the eligibility criteria. Only 5 studies met the eligibility criteria, and they were included in the analysis. These 5 studies with a pooled sample size of 295 diabetic nephropathy patients had an overall correlation coefficient r=0.694 (95% CI: 0.575-0.784) for disease severity and levels of urinary MCP-1.

Conclusion: Our results indicate that inflammatory biomarker urinary MCP-1 is easy to measure and reproducible which may be used for more accurate prediction of the progression to end stage renal disease.