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XRCC1 gene rs25487, rs1799782 polymorphisms do not influence the susceptibility of CAD

Ying-Nan Wang, De-Wei Wang, Lei Gao, Shi-Yong Wu, Dong-Yin Zhang, Shu Qin

Background: Two meta-analyses assessed the association between X-Ray Repair Cross Complementing 1 (XRCC1) gene polymorphisms and Coronary Artery Disease (CAD) risk. However, these two metaanalyses all included the studies without Hardy-Weinberg equilibrium (HWE). Therefore, their results were not reliable.

Methods: PubMed, EMBASE, MEDLINE, and the Cochrane Library were searched up to May 2017. Odds Ratios (OR) and 95% Confidence Interval (CI) were evaluated to determine the strength.

Results: Five case-control studies with 1715 cases and 1520 controls were included in this meta-analysis. A significant association was not found between XRCC1 rs25487 polymorphism and CAD risk (OR=0.93; 95% CI, 0.72-1.21; P=0.61). No significant association was found between XRCC1 rs25487 polymorphism and CAD risk in Caucasian (OR=0.93; 95% CI, 0.63-1.39; P=0.74) and Asian (OR=0.93; 95% CI, 0.50-1.75; P=0.83). A significant association was also not found between XRCC1 rs1799782 polymorphism and CAD risk (OR=1.07; 95% CI, 0.92-1.25; P=0.39). In the Caucasian subgroup, no significant association was observed (OR=1.07; 95% CI, 0.92-1.25; P=0.39).

Conclusions: This meta-analysis suggested that XRCC1 gene rs25487, rs1799782 polymorphisms were not associated with CAD risk.