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Mitochondrial DNA Copy Number and Brain MRI Markers: Implications for Brain Health and Neurological Disorders

Harry Warner

Mitochondrial DNA (mtDNA) copy number has been found to be associated with various health conditions, including neurological disorders. In recent years, researchers have explored the relationship between mtDNA copy number and brain magnetic resonance imaging (MRI) markers, which can provide important information about brain structure and function. This article reviews two studies that investigated the association between mtDNA copy number and brain MRI markers in older adults and individuals with mild cognitive impairment (MCI). The first study found that higher mtDNA copy number was associated with larger brain volume, particularly in the gray matter, and better white matter integrity in older adults. The second study found that lower mtDNA copy number was associated with smaller brain volume, particularly in the hippocampus, and greater white matter hyperintensities in individuals with MCI