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Prognostic factors for COVID-19 pneumonia with severe acute respiratory distress syndrome: An observational study.

Jinzhi Lu, Liya Zhu, Ying Xiong, Xiangqiong Liu, Zhiqiang Liu, ChenqiXin, Yujiechen, Cunjian Yi

Objective: To identify the prognostic factors of the coronavirus disease 2019 (Covid-19) pneumonia patients with severe acute respiratory distress syndrome (ARDS). Design and methods: 45 Covid-19 pneumonia patients with ARDS were included, who were hospitalized at The First Affiliated Hospital of Yangtze University in Jingzhou, Hubei, China, between January 22, 2020, and March 6, 2020. Clinical data and outcomes were reviewed and analyzed according to the Berlin definition. Results: Males were more likely to develop severe ARDS (11 [91.7%] in males vs. 1 [8.3%] in females). Several factors related to the development of Severe ARDS had been found in this study, which included sex (male) (HR, 13.75; 95% CI, 1.45-130.24), Neutrophil Count (HR, 55.00; 95% CI, 5.02-602.15), Lymphocyte Counts (HR, 40.00; 95% CI, 4.83-331.00), Pro-Thrombin Time (HR, 12.14; 95% CI, 1.19-123.62), D-Dimer (HR, 11.00; 95% CI, 1.16-103.94), Total Bilirubin (HR, 5.00; 95% CI, 0.93-26.79), Albumin (HR, 17.5; 95% CI, 2.67-114.85), Blood Urea Nitrogen (HR, 28.60; 95% CI, 2.89-283.06), Lactate Dehydrogenase (HR, 6.00; 95% CI, 1.17-30.73), C-Reactive Protein (HR, 15.87; 95% CI, 2.40-111.11). Conclusion: Laboratory tests such as neutrophil count and lymphocyte Counts could play an important role in the diagnosis of severe ARDS and guide treatment decision-making for ARDS patients.