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Effects of hesperidin supplementation on weight , glycemic control, lipid profile and inflammatory factors in patients with type 2 diabetes: A Randomized, Double-Blind and Clinical Trial Placebo-Controlled

Shahryar Eghtesadi

 This study was conducted to investigate the effects of hesperidin (a common constituent of citrus fruits) supplementation on weight ,indices of glycemic control, insulin resistance, lipid profile, and inflammatory markers in patients with type 2 diabetes. Forty-five patients participated in this randomized, double-blind controlled clinical trial who were randomly assigned to 2 intervention and control groups. Participants consumed either 500 mg/d pure hesperidin supplement or placebo in the intervention and control groups for 8 weeks, respectively. Hesperidin supplementation led to significant decrease in fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) (p = 0.041 and p = 0.028, respectively). A significant increase in serum insulin (p = 0.018) and decrease in total cholesterol (p = 0.049) were also observed in the hesperidin group, whereas no significant changes occurred in the placebo group. Inflammatory factors, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were not significantly changed in the hesperidin group compared to the control group. In conclusion hesperidin supplementation lowered the plasma level of total cholesterol and improved glycemic control and insulin resistance in patients with type 2 diabetes.